Set in modern-day Hawaii, Doogie Kameāloha, M.D. follows Lahela "Doogie" Kameāloha, a mixed race 16-year-old girl, juggling a budding medical career and life as a teenager. Guiding Lahela (and also complicating things) is her family, including her spit-fire Irish mother who's also her supervisor at the hospital, and her Hawaiian "Local Boy" father struggling to accept that his daughter is no longer his little girl.