Dr. John Dolittle lives in a small English village where he specializes in caring for and verbally communicating with animals. When Dr. Dolittle is unjustly sent to an insane asylum for freeing a lovesick seal from captivity, his animals and two closest human friends, Matthew Mugg and Tommy Stubbins, liberate him. Afterward, they join Emma Fairfax and set out by boat to find a famed and elusive creature: the Great Pink Sea Snail.