Stoners Larnell, Brett, and Bachman all suffer from severe delayed side effects from smoking grass from evil bong Ebee. The trio embark on a journey to the jungle in South America along with their nerdy straight-laced buddy Allistair and delivery guy Rabbit to find a cure for their various ailments. During their expedition the group encounters a bunch of beautiful women known as the Poontang tribe as well as a wicked and powerful bong called King Bong.